Abstract
A series of serotonin 5-HT1B ligands were synthesized and evaluated for their potency and selectivity against other 5-HT receptor subtypes. Many of these new compounds displayed high affinity and selectivity for the 5-HT1B receptor and compound 6c was found to have the in vitro binding profile necessary for development as a PET radioligand.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amides
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Humans
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Ligands
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Piperazines
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Protein Binding
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Radioligand Assay
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Receptor, Serotonin, 5-HT1B / chemistry
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Receptor, Serotonin, 5-HT1B / metabolism*
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Serotonin Agents / chemical synthesis*
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Serotonin Agents / chemistry
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Structure-Activity Relationship
Substances
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Amides
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Ligands
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Piperazines
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Receptor, Serotonin, 5-HT1B
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Serotonin Agents
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phenylpiperazine